Scientists have long known about intestinal receptors called TAS2R, which, as previous studies have shown, influence metabolism, hormone production, and other processes. In a new study, a team from Spain set out to evaluate the influence of TAS2R on changes in the body as we age. New Atlas reports on their findings.
The experiment involved two groups of volunteers: men and women aged 20 to 50, and participants aged 50 to 80. In the first stage, all participants underwent a colonoscopy to collect samples of the colonic mucosa. The scientists then analyzed biomarkers that change with aging, such as inflammation, lipids, hormones, and other indicators.
As a result, two receptors were identified that are most important for aging. The first, called TAS2R5, was associated with changes in various types of lipoproteins, while the second, TAS2R38, was associated with sphingomyelin, a lipid present in all cell membranes. It accumulates with aging and causes cellular dysfunction.
"Both receptors may play a key role in understanding aging processes. They are located in the gut, so we can develop preventative measures based on their interactions with food and microbiota," said study co-author Anna Ardevol.
Recently, in preclinical experiments, scientists demonstrated that administering mRNA to laboratory animals promotes rejuvenation. The treatment increased lifespan and reduced signs of aging.
