Scientists have long known about intestinal receptors TAS2R, which, as previous studies have shown, affect metabolism, hormone production, and other processes. In their new work, a team from Spain decided to evaluate the influence of TAS2R on changes in the body as we age. New Atlas writes about the findings.
The experiment involved two groups of volunteers: men and women aged 20 to 50 years, and participants aged 50 to 80 years. In the first stage, everyone underwent a colonoscopy to collect samples of the colon mucosa. Then, the scientists analyzed biomarkers that change with aging. For example, they assessed inflammation indicators, lipids, hormones, and other indicators.
As a result, two receptors were identified that are most important for aging. The first, called TAS2R5, was associated with changes in different types of lipoproteins, and the second, TAS2R38, with sphingomyelin, a lipid present in all cell membranes. It accumulates as we age and causes cellular dysfunction.
"Both receptors may play a key role in understanding the aging process. They are located in the gut, so we can develop preventive measures based on their interaction with food and microbiota," said co-author Anna Ardevol.
Recently, scientists have shown in preclinical experiments that administering mRNA to laboratory animals promotes rejuvenation. The treatment increased lifespan and reduced signs of aging.
