It's summer, everyone wants to show their excellent physical shape, but some people have not been able to do it for years, because they are overweight and can't get rid of it)
How to reverse this situation and finally lose weight? I will tell you about it below.
And so, in every cell, every person has a kind of molecular sensor of the energy state: AMP-activated protein kinase, AMPK, or AMPK in English.
It sounds complicated, but the function of this protein kinase is relatively simple. As soon as there is a shortage of energy in the cell (not enough adenosine triphosphate, ATP, or "energy molecule") this protein kinase starts a series of cascades through phosphorylation to save energy (ATP).
If you have driven a Tesla, you know how its on-board computer cuts off everything unnecessary when there is little battery power left. Every cell of the organism behaves in the same way, for example, when there is a shortage of food or high energy consumption for physical activity. In the language of physiology, catabolic processes begin to take place in the cell in case of energy deficiency. This is the body's search for energy sources. And where we have a "cellar" with energy? Right, in fat 🙂 Or fat cells - adipocytes.
What's my point? 🙂 🙂
To lose weight you need to activate the AMFC. How do you do that in the most trivial way? - Exercise and hunger. But not everyone has time to exercise every day and not everyone has the willpower to starve 🙂 🙂
How to trick the body?- Take AMPK activators.
The simplest, most affordable and effective example is the supplement berberine. It's an alkaloid from barberry. You can buy it on iherb.
It works clearly, but should not be taken by people with low fasting glucose.
Examples of other AMPK activators can be found on google by searching "ampk activators"
By combining such supplements with workouts you can achieve amazing results in as little as a month. Go for it 🙂 🙂
Evidence citations:
https://pubmed.ncbi.nlm.nih.gov/32353823/
https://pubmed.ncbi.nlm.nih.gov/25423280/
https://pubmed.ncbi.nlm.nih.gov/26577614/
