It's summer, and everyone wants to show off their great physical shape, but some haven't been able to for years, hampered by excess weight that just can't seem to get rid of it.
How can you reverse this situation and finally lose weight? I'll explain below.
So, in every cell of every person, there's a kind of molecular energy sensor: AMP-activated protein kinase, or AMPK.
It sounds complicated, but the function of this protein kinase is relatively simple. As soon as a cell experiences an energy deficit (low adenosine triphosphate, or ATP, or "energy molecule"), this protein kinase, through phosphorylation, initiates a series of cascades to conserve energy (ATP).
Anyone who's driven a Tesla knows how its onboard computer shuts off all unnecessary functions when the battery is low. Every cell in the body behaves similarly, for example, during a lack of food or high energy expenditure during physical activity. In physiological terms, when a cell experiences an energy deficit, catabolic processes begin. This is the body's search for energy sources. Where is our energy "cellar"? That's right, in fat, 
or fat cells—adipocytes.
What am I getting at?
To lose weight, you need to activate AMPK. How can you do this simply? Exercise and fasting. But not everyone has the time to exercise every day or the willpower to fast.
How to trick your body? Take AMPK activators.
The simplest, most accessible, and most effective example is the supplement berberine . It's an alkaloid found in barberry. You can buy it on iHerb.
It works reliably, but it shouldn't be taken by people with low fasting glucose levels.
You can find examples of other AMPK activators by googling "ampk activators."
Combining such supplements with exercise can achieve amazing results in just a month. Go for it.
Links to evidence:
https://pubmed.ncbi.nlm.nih.gov/32353823/
https://pubmed.ncbi.nlm.nih.gov/25423280/
https://pubmed.ncbi.nlm.nih.gov/26577614/
