Summer, everyone wants to show off their excellent physical shape, but some have not been able to do this for years, excess weight that they can’t get rid of)
How to turn this situation around and finally lose weight? I will tell you about this below.
So, in each cell of each person there is a kind of molecular sensor of the energy state: AMP-activated protein kinase, AMPK, or AMPK in English.
It sounds complicated, but the function of this protein kinase is relatively simple. As soon as there is an energy deficit in the cell (little adenosine triphosphate, ATP, or “energy molecule”), this protein kinase, through phosphorylation, launches a series of cascades to save energy (ATP).
Anyone who has driven a Tesla knows how its on-board computer cuts off everything unnecessary when the battery charge is low. Every cell in the body behaves in exactly the same way, for example, when there is a lack of food or a large energy expenditure on physical activity. In the language of physiology, when there is a deficit of energy in the cell, catabolism processes begin to occur. This is the body's search for energy sources. And where is our "cellar" with energy? That's right, in fat 
or fat cells - adipocytes.
What am I getting at?
In order to lose weight, you need to activate AMPK. How can you do this simply? - Physical exercise and hunger. But not everyone has time to exercise every day and not everyone has the willpower to fast.
How to trick the body? - Take AMPK activators.
The simplest, most accessible and effective example is the supplement berberine . This is an alkaloid from barberry. You can buy it on iHerb.
It works well, but it should not be taken by people with low fasting glucose levels.
You can find examples of other AMPK activators in Google by searching for "ampk activators".
By combining such supplements with training, you can achieve amazing results in just a month. Go for it.
Links to evidence:
https://pubmed.ncbi.nlm.nih.gov/32353823/
https://pubmed.ncbi.nlm.nih.gov/25423280/
https://pubmed.ncbi.nlm.nih.gov/26577614/
