As you have already noticed, I often criticize various medications that are being imposed on us more and more every year. Of course, I understand what big business is and that the top management of pharmaceutical companies needs to maintain their business jets for flights to Ibiza 
BUT people who need treatment, as well as doctors who prescribe treatment for them, do not understand this.
This post will talk about a drug that gave false hope to many patients and which was the most expensive drug in the world (~$2 million - 1 injection). We are talking about Zolgensma (Onasemnogene Abeparvovec).
I don't know who comes up with such complicated names for these drugs, but as it turns out, they are also tested by NOT very smart guys (Although it may be the other way around 
)
In short, there is a group of incurable diseases under the general name - spinal muscular atrophy. So, the businessmen from Big Fara harnessed scientists to develop a drug that cures this matter, using new techniques for modifying the patient's genes (like a viral vector in the vaccine-"blood clot generator" - AstraZeneca).
Scientists thought about it, found defective genes that needed to be fixed, and rolled out an experimental drug. Then they started testing it on mice. The control group of sick mice were injected with a viral vector of green fluorescent protein, and the experimental group was injected with the drug itself. Well, the logic is simple: if sick mice with the drug outlive sick mice without the drug, then it's in the bag. And according to the first statements of scientists, they outlived and lived a full life. In 2019, the FDA approved Zolgensma , i.e. they confirmed that the drug is safe and effective.
The drug was rolled out onto the market, and various medical institutions began to use it. The state and various funds paid the pharmaceutical company-manufacturer for supplying the drug to their patients. Relatives of thousands of patients saw this as a panacea, although, in fact, the drug does not make patients healthy , which personally makes me feel wildly inappropriate about such therapy. After all, why prolong a person's suffering and even pay 2 million for it? It sounds cruel, but this is strictly my opinion.
In short, big pharma started to make its profit; And this continued until patients started to die after injections. These patients were 2 children from Russia and Kazakhstan. These were the first deaths after this drug. Of course, they write that the causes of death there are different, but I had doubts and perhaps my intuition did not fail me this time:
This month, interesting facts began to emerge : A 2010 scientific publication describing experiments on mice was retracted . It turned out that during the experiments, the researchers inaccurately recorded the results of observations of the mice, and unverified data ended up in the report.
Somewhere the described lifespan of mice differed from the real one by a couple of days, and somewhere - by as much as 19 days. Personally, I am perplexed by this information. The company itself announced this and began to fire responsible employees and conduct a secret (!) investigation.
The most interesting thing about this story is that the FDA “gurus” were not embarrassed. The decision was made not to recall the drug from the market, I quote “experts”: “the inaccuracies found do NOT affect patient safety or the effectiveness and quality of the product.” Although, in fact, the safety and effectiveness of this product have not yet been 100% established.
Who believes them? I certainly don't . Now think about how much more of this possible(!) fake science is in other new drugs?
https://www.nature.com/articles/nbt.1610
