I think everyone has heard of this drug, but not everyone understands how it actually works: Ozempic (active ingredient - semaglutide) is a glucagon-like peptide-1 (GLP-1) mimetic . A mimetic is a substance that imitates (imitates) the action of another substance in the body. In this case, glucagon-like peptide-1. This hormone has an interesting and comprehensive effect on the body - it does everything so that the body quickly utilizes all energy substrates in the body - glucose, fat.
Why is this necessary? Evolutionarily, our body had to receive the maximum amount of energy in the shortest time. After all, in an aggressive environment, our ancestors received food less often than now. At the same time, the body's cells needed to use glucose effectively, i.e. "eat" it quickly, synthesize ATP (adenositrolphosphate), start anabolic processes (division and growth processes). In all this, the body was and is helped by glucagon-like peptide-1, which Ozempic is similar to in biochemical terms. GLP-1 or Ozempic starts the following processes in the body (the main ones):
- Reduces stomach activity (eg less acid)
- Temporarily increases insulin secretion (under the influence of insulin, glucose enters the cells)
- Temporarily increases growth hormone
- Stimulates the secretion of TSH (what makes the thyroid gland work to synthesize its hormones). The more thyroid hormones, the thinner the person (roughly speaking)
Sounds only positive, doesn't it? But in practice it turned out with nuances. It turned out that with an excess of GLP-1, or its mimetics, not all organisms can handle such a load on the pancreas and thyroid glands. After all, who checks them before starting therapy?
So, if a person was initially healthy and simply overate from the excess of benefits in his life, then Ozempic can solve his problems effectively. But what if we have a sick person who is overweight due to crooked genes for the thyroid gland, for the pancreas, who has various infections, and problems with various glands?? Then with Ozempic we will get even more problems, in the worst case, thyroid cancer or pancreatitis.
The cunning pharmaceutical companies write about this in the instructions for this drug. My favorite analogy in this case is accelerating a car on the highway. A bad car will fall apart at high speed. A new one will drive in one piece. In order for an old one to drive for a long time, it does not need to be accelerated. So here, a sick organism does not need to be accelerated with Ozempiks and other hormones. This is an axiom.
What is the alternative to Ozempic? I wrote about it earlier. Yes, it is not as effective due to bioavailability, but it is safe and cheap - it is Berberine . In order not to be verbose, I will quote someone else's words about Ozempic and Berberine from someone else's video:
