Scientists have presented an experimental treatment for various musculoskeletal diseases from osteoporosis to spondylitis. They have discovered a peptide that regulates bone remodeling, restoring cellular balance.
A team from the University of Birmingham presented the results of research into the bone-rebuilding peptide PEPITEM . According to the findings, the PEPITEM protein enhances bone mineralization, formation and density, and reverses bone loss.
PEPITEM has clear advantages over existing drugs such as bisphosphonates , which block the action of osteoclasts. The peptide does not interfere with the ability of osteoclasts to remove damaged bone tissue, but it enhances the action of bone-forming osteoblasts.
Working with human cell cultures, the scientists confirmed their results and found that the peptide increases the activity of osteoblasts, not their number. Further studies should confirm the prospects and safety of the treatment for humans.