Many bacteria, including MRSA, have mesh-like cell walls that use enzymes to adhere to each other. These enzymes are targets for antibiotics such as penicillin and methicillin. In recent years, scientists have discovered that MRSA exploits a specific cell wall enzyme to develop antibiotic resistance. In a new study, a team from the University of Sheffield demonstrated that there is another pathway that ensures the superbug's survival.
It turns out that an additional defense mechanism allows MRSA to replicate in the presence of antibiotics. "This discovery not only reveals a vulnerability in the superbug but also demonstrates an alternative mode of bacterial division. These results provide new insights into the fundamental principles underlying bacterial growth and division," the authors commented.
They have already begun developing inhibitors to block this new target. Further research will demonstrate the potential benefits of this strategy for other infections.
Previously, other scientists presented an antibiotic that destroys all resistant strains of Staphylococcus aureus and also restores the bacteria's sensitivity to existing antibiotics.
