A team from Oregon State University has presented a technology based on microscopic scaffolds that guide cells toward proper muscle tissue repair. Stimulating muscle regeneration is typically very difficult due to the complex organization of muscle fibers. The scientists solved this problem by using scaffolds that guide cells along the desired trajectory.
Scaffolds made of biocompatible polymers, less than 1/10 the thickness of a human hair, with added hyaluronic acid provided an excellent microenvironment for growing tissue with the desired structure: cells successfully attached and aligned into functional structures. Subsequently, the cells successfully grew and differentiated along the scaffolds in an organized manner.
"We're still a long way from applying this technology to the human body, but we've made a significant step toward developing effective treatments for extensive muscle damage. Treatment can be tailored to specific injury types and patient needs," the authors stated. They are currently exploring the potential of other growth factors to ensure a more versatile approach for a variety of conditions.
Scientists recently discovered a mechanism for regenerating old muscles. It turns out that exercise restores key cellular balance in aging muscles, helping them remain stronger and more resilient.
